An entheogen, in the strictest sense, is a psychoactive substance used in a religious or shamanic context. Entheogens generally come from plant sources which contain molecules closely related to endogenous neurochemicals. They occur in a wide variety of sacraments of various religious rites and have been shown (Good Friday Experiment) to directly provoke what users perceive as spiritual/mystical experiences.
Examples are far reaching ancient sources predating the modern era: such as Hebrew: manna; Greek: kykeon; African: Iboga; Vedic: Soma, Amrit. Entheogens have been safely utilized in a religious context for thousands of years.
Source: Wikipedia
http://en.wikipedia.org/wiki/Entheogen
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